Tenured Scientist at Institute of Physical Chemistry Blas Cabrera, CSIC, Spain
Dr. José Manuel Martín García is an accomplished structural biologist whose career bridges advanced macromolecular crystallography and the development of innovative techniques for protein structure determination. Currently a Científico Titular at the Instituto de Química Física Blas Cabrera (IQF-CSIC) in Madrid, Spain, Dr. Martín García has spent over a decade pioneering serial crystallography methods using synchrotrons and X-ray free-electron lasers (XFELs). With an extensive publication record, he continues to make significant contributions to structural biology, focusing on understanding complex biological systems and drug discovery at the molecular level.
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Education
Dr. Martín García completed his Licenciatura in Chemistry in 2004 at the University of Granada, Spain. He pursued his passion for structural studies further by earning a Ph.D. in Chemistry from the same university in 2010. His doctoral work laid the groundwork for his lifelong focus on the structural dynamics of proteins, utilizing state-of-the-art crystallography tools and methods.
Experience
Following his doctorate, Dr. Martín García embarked on extensive postdoctoral research. Between 2010 and 2011, he was a Postdoctoral Research Associate at the University of Almería, Spain. He then moved to the Arizona State University (ASU), USA, where he served as Postdoctoral Research Associate (2011–2015), Assistant Research Scientist (2015–2019), and Associate Research Scientist (2019–2020). During this period, he became a key figure in advancing nano-crystallography, microfluidic delivery methods, and sample-efficient time-resolved serial femtosecond crystallography. Returning to Spain, he secured a prestigious Atracción de Talento contract with the Comunidad de Madrid (2020–2024) before his current appointment at CSIC.
Research Interest
Dr. Martín García’s research interests focus on time-resolved serial crystallography, dynamic studies of cancer-related processes and antibiotic resistance, and developing novel techniques for growing and delivering nanocrystals for high-resolution imaging. His work integrates nanotechnology, microfluidics, and computational tools to push the boundaries of how proteins are visualized in motion, offering new insights for structure-based drug discovery and understanding complex enzymatic mechanisms.
Awards
Dr. Martín García’s scientific excellence has been recognized with notable awards and certifications. He received the I3 Certification in 2022 with an outstanding score, confirming his impact in Spanish research. His teaching and research achievements have also been positively evaluated by ANECA, qualifying him for university faculty positions. He has won best poster prizes and received distinctions from ASU for his pioneering work in structural biology. Furthermore, he actively contributes as an editor for high-impact journals, including Crystals and Frontiers in Molecular Biosciences, and is a sought-after evaluator for international science foundations like HFSP and SNSF.
Publications
Dr. Martín García’s prolific output includes over 50 scientific articles. Selected works include:
- “Heterogeneity in M. tuberculosis β-lactamase inhibition by Sulbactam”, Nat Commun. (2023) — cited for revealing new antibiotic resistance mechanisms.
- “Room-temperature structural studies of SARS-CoV-2 protein NendoU with an XFEL”, Structure (2023) — provided key insights for COVID-19 research.
- “Structural dynamics and functional cooperativity of human NQO1”, Protein Sci. (2024) — advanced understanding of cancer-related enzymes.
- “New insights into Ferredoxin-NADP+ reductase from Brucella ovis”, Arch Biochem Biophys. (2024) — contributed to pathogen structural biology.
- “Cyclic Olefin Copolymer-Based Sample Delivery Device”, Anal Chem. (2024) — introduced cutting-edge microfluidic solutions for crystallography.
- “Innovative Strategies in X-ray Crystallography for Metabolic Disorders”, J Pers Med. (2024) — a review bridging structural biology and personalized medicine.
- “Macromolecular Serial Crystallography at ALBA Synchrotron”, J Synchrotron Radiat. (2022) — demonstrated practical advances for European XFEL facilities.
Each of these articles has contributed significantly to high-impact journals, collectively earning him over 1,500 citations and an h-index of 18.
Conclusion
In summary, Dr. José Manuel Martín García exemplifies modern interdisciplinary science — blending chemistry, physics, biology, and engineering to unlock the secrets of life at the atomic level. His career reflects a commitment to collaboration and innovation, mentoring emerging scientists, publishing extensively, and sharing knowledge through international talks and editorial roles. With his continued focus on time-resolved crystallography and structural dynamics, he remains a key driver of discoveries that inform therapeutic development and deepen our understanding of life’s molecular machinery.